Drug interactions
Chlorpropamide + Sulindac
Severity: Minor
Chlorpropamide and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some NSAIDs may enhance the glucose-lowering effect of sulfonylureas, raising the possibility of hypoglycemia. Evidence for sulindac specifically is limited, and the effect is likely small.
What this interaction means in plain words
Chlorpropamide and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Sulindac belongs to Musculoskeletal.
Why it happens
Possible displacement from plasma protein binding or reduced clearance of the sulfonylurea; the mechanism is not firmly established.
What to do
Counsel patients on hypoglycemia symptoms and check blood glucose more often when starting or stopping sulindac. Reduce the chlorpropamide dose if low readings occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Sulindac?
MediHelp rates the interaction as minor. Chlorpropamide and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some NSAIDs may enhance the glucose-lowering effect of sulfonylureas, raising the possibility of hypoglycemia. Evidence for sulindac specifically is limited, and the effect is likely small.
How serious is the interaction between Chlorpropamide and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on hypoglycemia symptoms and check blood glucose more often when starting or stopping sulindac. Reduce the chlorpropamide dose if low readings occur.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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