Drug interactions
Chlorpropamide + Tolfenamic acid
Severity: Moderate
Chlorpropamide and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can potentiate the hypoglycemic effect of sulfonylureas. Tolfenamic acid may therefore increase the risk of hypoglycemia with chlorpropamide, and NSAID-related renal effects may prolong chlorpropamide exposure.
What this interaction means in plain words
Chlorpropamide and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement and reduced renal elimination; not firmly established.
What to do
Monitor blood glucose when starting or stopping tolfenamic acid and reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpropamide and Tolfenamic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorpropamide
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Chlorpropamide with Tolfenamic acid?
MediHelp rates the interaction as moderate. Chlorpropamide and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can potentiate the hypoglycemic effect of sulfonylureas. Tolfenamic acid may therefore increase the risk of hypoglycemia with chlorpropamide, and NSAID-related renal effects may prolong chlorpropamide exposure.
How serious is the interaction between Chlorpropamide and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping tolfenamic acid and reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
