Drug interactions
Chlorpropamide + Ziprasidone
Severity: Minor
Chlorpropamide and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone has a lower metabolic risk than some atypicals but can still alter glucose in some patients. This may reduce control in patients treated with chlorpropamide.
What this interaction means in plain words
Chlorpropamide and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Ziprasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition from antipsychotic effects on glucose metabolism.
What to do
Monitor blood glucose when ziprasidone is started or the dose changed. Adjust the chlorpropamide dose if glycemic control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Ziprasidone?
MediHelp rates the interaction as minor. Chlorpropamide and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ziprasidone has a lower metabolic risk than some atypicals but can still alter glucose in some patients. This may reduce control in patients treated with chlorpropamide.
How serious is the interaction between Chlorpropamide and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ziprasidone is started or the dose changed. Adjust the chlorpropamide dose if glycemic control worsens.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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