Drug interactions
Chlorthalidone + Colestipol
Severity: Moderate
Chlorthalidone and Colestipol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bile acid sequestrants bind thiazide-type diuretics in the gut and can lower their absorption, potentially weakening the diuretic and antihypertensive effect.
What this interaction means in plain words
Chlorthalidone and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Colestipol belongs to Cardiovascular.
Why it happens
Colestipol binds chlorthalidone in the gastrointestinal tract, reducing its absorption.
What to do
Give chlorthalidone at least 1 hour before or 4 hours after colestipol. Monitor blood pressure and edema control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Chlorthalidone with Colestipol?
MediHelp rates the interaction as moderate. Chlorthalidone and Colestipol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bile acid sequestrants bind thiazide-type diuretics in the gut and can lower their absorption, potentially weakening the diuretic and antihypertensive effect.
How serious is the interaction between Chlorthalidone and Colestipol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give chlorthalidone at least 1 hour before or 4 hours after colestipol. Monitor blood pressure and edema control.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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