Drug interactions
Chlorthalidone + Dapagliflozin-metformin
Severity: Moderate
Chlorthalidone and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-type diuretics such as chlorthalidone can raise blood glucose, particularly at higher doses, and may reduce the effect of antidiabetic drugs. Volume depletion may also add to the diuretic effect of dapagliflozin.
What this interaction means in plain words
Chlorthalidone and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism via thiazide-induced hypokalemia and impaired insulin secretion and sensitivity, plus additive diuresis.
What to do
Monitor blood glucose, electrolytes and volume status, and adjust antidiabetic therapy or diuretic dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Chlorthalidone and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-type diuretics such as chlorthalidone can raise blood glucose, particularly at higher doses, and may reduce the effect of antidiabetic drugs. Volume depletion may also add to the diuretic effect of dapagliflozin.
How serious is the interaction between Chlorthalidone and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, electrolytes and volume status, and adjust antidiabetic therapy or diuretic dose if needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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