Drug interactions
Chlorthalidone + Diazoxide
Severity: Moderate
Chlorthalidone and Diazoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise blood glucose, and combined use can cause or worsen hyperglycemia. They may also add to hypotension and hypokalemia.
What this interaction means in plain words
Chlorthalidone and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Diazoxide belongs to Miscellaneous.
Why it happens
Additive hyperglycemic effects through reduced insulin secretion (diazoxide) and impaired glucose tolerance with thiazide-type diuretics.
What to do
Monitor blood glucose, potassium and blood pressure. Adjust antidiabetic therapy or diazoxide dose if glucose rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Diazoxide
Frequently asked questions
Can I take Chlorthalidone with Diazoxide?
MediHelp rates the interaction as moderate. Chlorthalidone and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs raise blood glucose, and combined use can cause or worsen hyperglycemia. They may also add to hypotension and hypokalemia.
How serious is the interaction between Chlorthalidone and Diazoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, potassium and blood pressure. Adjust antidiabetic therapy or diazoxide dose if glucose rises.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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