Drug interactions
Chlorthalidone + Diclofenac
Severity: Moderate
Chlorthalidone and Diclofenac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac may reduce the diuretic and antihypertensive effect of chlorthalidone and increase the risk of renal impairment in volume-depleted patients.
What this interaction means in plain words
Chlorthalidone and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Diclofenac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and lowers renal blood flow.
What to do
Monitor blood pressure, renal function and electrolytes, and adjust the antihypertensive regimen if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Diclofenac?
MediHelp rates the interaction as moderate. Chlorthalidone and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac may reduce the diuretic and antihypertensive effect of chlorthalidone and increase the risk of renal impairment in volume-depleted patients.
How serious is the interaction between Chlorthalidone and Diclofenac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and adjust the antihypertensive regimen if control is lost.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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