Drug interactions
Chlorthalidone + Diflunisal
Severity: Moderate
Chlorthalidone and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and antihypertensive effect of thiazide-type diuretics. Together they may also raise the risk of acute kidney injury, especially in volume-depleted or elderly patients.
What this interaction means in plain words
Chlorthalidone and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Diflunisal belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal blood flow, opposing diuretic action.
What to do
Monitor blood pressure, fluid status, and renal function and electrolytes when the combination is used. Keep the patient well hydrated and adjust diuretic dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Diflunisal?
MediHelp rates the interaction as moderate. Chlorthalidone and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and antihypertensive effect of thiazide-type diuretics. Together they may also raise the risk of acute kidney injury, especially in volume-depleted or elderly patients.
How serious is the interaction between Chlorthalidone and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, and renal function and electrolytes when the combination is used. Keep the patient well hydrated and adjust diuretic dose if control worsens.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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