Drug interactions
Chlorthalidone + Enalapril-hydrochlorothiazide
Severity: Moderate
Chlorthalidone and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hypotension. Renal function may also decline.
What this interaction means in plain words
Chlorthalidone and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive diuretic and electrolyte-wasting effects from two thiazide-type agents acting at the distal tubule.
What to do
Avoid duplicate thiazide therapy and use only one agent. If continued deliberately, monitor potassium, sodium, magnesium and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Chlorthalidone and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypomagnesemia, volume depletion and hypotension. Renal function may also decline.
How serious is the interaction between Chlorthalidone and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate thiazide therapy and use only one agent. If continued deliberately, monitor potassium, sodium, magnesium and renal function.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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