Drug interactions
Chlorthalidone + Etodolac
Severity: Moderate
Chlorthalidone and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac can reduce the diuretic and antihypertensive effect of chlorthalidone. The combination also raises the risk of renal impairment, particularly with volume depletion.
What this interaction means in plain words
Chlorthalidone and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, causing sodium and water retention and reduced renal perfusion.
What to do
Monitor blood pressure, edema and renal function, and keep the patient well hydrated. Adjust the antihypertensive regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Etodolac?
MediHelp rates the interaction as moderate. Chlorthalidone and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etodolac can reduce the diuretic and antihypertensive effect of chlorthalidone. The combination also raises the risk of renal impairment, particularly with volume depletion.
How serious is the interaction between Chlorthalidone and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and renal function, and keep the patient well hydrated. Adjust the antihypertensive regimen if control worsens.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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