Drug interactions
Chlorthalidone + Fluticasone-vilanterol
Severity: Moderate
Chlorthalidone and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone causes renal potassium loss, and vilanterol can further lower serum potassium through cellular uptake. The combination may increase the risk of hypokalemia and related ECG changes, especially in patients with cardiac disease.
What this interaction means in plain words
Chlorthalidone and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive hypokalemia from thiazide-like diuretic potassium wasting and beta2-mediated intracellular potassium shift.
What to do
Monitor serum potassium and magnesium, especially when starting therapy or in high-risk patients, and supplement if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorthalidone and Fluticasone-vilanterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluticasone-vilanterol
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Chlorthalidone and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone causes renal potassium loss, and vilanterol can further lower serum potassium through cellular uptake. The combination may increase the risk of hypokalemia and related ECG changes, especially in patients with cardiac disease.
How serious is the interaction between Chlorthalidone and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, especially when starting therapy or in high-risk patients, and supplement if low.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
