Drug interactions
Chlorthalidone + Folic acid
Severity: Minor
Chlorthalidone and Folic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may increase urinary loss of folate, potentially lowering folate levels over time. Clinically relevant deficiency is uncommon and mainly a concern with poor intake or other risk factors. The effect is generally small.
What this interaction means in plain words
Chlorthalidone and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorthalidone belongs to Cardiovascular; Folic acid belongs to Miscellaneous.
Why it happens
Possible increased renal elimination of folate; the evidence for this mechanism is limited.
What to do
No routine action is required; check folate status in patients with poor nutrition, alcohol use or anemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorthalidone
Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Frequently asked questions
Can I take Chlorthalidone with Folic acid?
MediHelp rates the interaction as minor. Chlorthalidone and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics may increase urinary loss of folate, potentially lowering folate levels over time. Clinically relevant deficiency is uncommon and mainly a concern with poor intake or other risk factors. The effect is generally small.
How serious is the interaction between Chlorthalidone and Folic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required; check folate status in patients with poor nutrition, alcohol use or anemia.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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