Drug interactions
Chlorthalidone + Formoterol-mometasone
Severity: Moderate
Chlorthalidone and Formoterol-mometasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone causes potassium loss, and formoterol shifts potassium into cells, so together they can produce additive hypokalemia, particularly at high beta-agonist doses. Inhaled mometasone adds little on its own. Hypokalemia increases arrhythmia risk, especially in patients with heart disease.
What this interaction means in plain words
Chlorthalidone and Formoterol-mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Formoterol-mometasone belongs to Respiratory.
Why it happens
Additive potassium lowering via renal loss from the thiazide-like diuretic and beta-2-mediated cellular uptake.
What to do
Monitor serum potassium and magnesium, especially during dose increases or acute exacerbations, and supplement as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Formoterol-mometasone?
MediHelp rates the interaction as moderate. Chlorthalidone and Formoterol-mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone causes potassium loss, and formoterol shifts potassium into cells, so together they can produce additive hypokalemia, particularly at high beta-agonist doses. Inhaled mometasone adds little on its own. Hypokalemia increases arrhythmia risk, especially in patients with heart disease.
How serious is the interaction between Chlorthalidone and Formoterol-mometasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, especially during dose increases or acute exacerbations, and supplement as needed.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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