Drug interactions
Chlorthalidone + Indomethacin
Severity: Moderate
Chlorthalidone and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can blunt the diuretic and antihypertensive effect of chlorthalidone. The combination also increases the risk of acute kidney injury, particularly in elderly or volume-depleted patients.
What this interaction means in plain words
Chlorthalidone and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and water retention and reduced renal perfusion, antagonizing thiazide-type diuretic effects.
What to do
Monitor blood pressure, fluid status, serum creatinine and electrolytes when starting or stopping indomethacin. Use the lowest effective NSAID dose for the shortest time and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Indomethacin?
MediHelp rates the interaction as moderate. Chlorthalidone and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can blunt the diuretic and antihypertensive effect of chlorthalidone. The combination also increases the risk of acute kidney injury, particularly in elderly or volume-depleted patients.
How serious is the interaction between Chlorthalidone and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, serum creatinine and electrolytes when starting or stopping indomethacin. Use the lowest effective NSAID dose for the shortest time and ensure adequate hydration.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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