Drug interactions
Chlorthalidone + Ketoprofen
Severity: Moderate
Chlorthalidone and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and antihypertensive effects of thiazide-type diuretics and may raise the risk of acute kidney injury, especially in volume-depleted or elderly patients. Fluid retention and loss of blood pressure control may occur.
What this interaction means in plain words
Chlorthalidone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal vasodilatory prostaglandins reduces renal blood flow and sodium excretion, opposing diuretic action.
What to do
Monitor blood pressure, edema, and serum creatinine and electrolytes, and ensure adequate hydration. Use the lowest effective ketoprofen dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Ketoprofen?
MediHelp rates the interaction as moderate. Chlorthalidone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and antihypertensive effects of thiazide-type diuretics and may raise the risk of acute kidney injury, especially in volume-depleted or elderly patients. Fluid retention and loss of blood pressure control may occur.
How serious is the interaction between Chlorthalidone and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema, and serum creatinine and electrolytes, and ensure adequate hydration. Use the lowest effective ketoprofen dose for the shortest time.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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