Drug interactions
Chlorthalidone + Methoxsalen
Severity: Moderate
Chlorthalidone and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone, like other thiazides, can cause photosensitivity, and methoxsalen is a potent photosensitizer used with UVA exposure. Combined use may increase the risk of exaggerated sunburn-like reactions or phototoxicity during PUVA therapy.
What this interaction means in plain words
Chlorthalidone and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive phototoxic effects of two photosensitizing drugs.
What to do
Monitor skin response during phototherapy and reduce UV dose if erythema is excessive. Advise strict sun protection and consider an alternative antihypertensive if reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorthalidone
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Chlorthalidone with Methoxsalen?
MediHelp rates the interaction as moderate. Chlorthalidone and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone, like other thiazides, can cause photosensitivity, and methoxsalen is a potent photosensitizer used with UVA exposure. Combined use may increase the risk of exaggerated sunburn-like reactions or phototoxicity during PUVA therapy.
How serious is the interaction between Chlorthalidone and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor skin response during phototherapy and reduce UV dose if erythema is excessive. Advise strict sun protection and consider an alternative antihypertensive if reactions occur.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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