Drug interactions
Chlorthalidone + Oxaprozin
Severity: Moderate
Chlorthalidone and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive and diuretic effect of thiazide-type diuretics and raise the risk of renal impairment, especially with volume depletion. Fluid retention may occur.
What this interaction means in plain words
Chlorthalidone and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins decreases renal perfusion and sodium excretion, opposing the diuretic effect.
What to do
Monitor blood pressure, edema and renal function, and keep the patient well hydrated. Use the lowest NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Oxaprozin?
MediHelp rates the interaction as moderate. Chlorthalidone and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive and diuretic effect of thiazide-type diuretics and raise the risk of renal impairment, especially with volume depletion. Fluid retention may occur.
How serious is the interaction between Chlorthalidone and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and renal function, and keep the patient well hydrated. Use the lowest NSAID dose for the shortest time.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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