Drug interactions
Chlorthalidone + Pivmecillinam
Severity: Minor
Chlorthalidone and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mecillinam, the active form of pivmecillinam, is eliminated renally, and the interaction with a thiazide-type diuretic is only theoretical. Any rise in beta-lactam levels would be small and the drug has a wide safety margin. Clinically meaningful effects are not documented.
What this interaction means in plain words
Chlorthalidone and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorthalidone belongs to Cardiovascular; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion; not well established for this pair.
What to do
No routine adjustment is needed. Monitor renal function and for beta-lactam adverse effects in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorthalidone
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Chlorthalidone with Pivmecillinam?
MediHelp rates the interaction as minor. Chlorthalidone and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mecillinam, the active form of pivmecillinam, is eliminated renally, and the interaction with a thiazide-type diuretic is only theoretical. Any rise in beta-lactam levels would be small and the drug has a wide safety margin. Clinically meaningful effects are not documented.
How serious is the interaction between Chlorthalidone and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor renal function and for beta-lactam adverse effects in patients with renal impairment.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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