Drug interactions
Chlorthalidone + Prednisone
Severity: Moderate
Chlorthalidone and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents promote potassium loss, so using them together increases the risk of hypokalemia. This may lead to weakness, muscle cramps and arrhythmias.
What this interaction means in plain words
Chlorthalidone and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Prednisone belongs to Endocrine.
Why it happens
Thiazide-like diuretic potassium wasting is added to the mineralocorticoid effect of prednisone.
What to do
Monitor serum potassium regularly and supplement potassium or add a potassium-sparing agent if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Prednisone?
MediHelp rates the interaction as moderate. Chlorthalidone and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents promote potassium loss, so using them together increases the risk of hypokalemia. This may lead to weakness, muscle cramps and arrhythmias.
How serious is the interaction between Chlorthalidone and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium regularly and supplement potassium or add a potassium-sparing agent if needed.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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