Drug interactions
Chlorthalidone + Sulindac
Severity: Moderate
Chlorthalidone and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive and diuretic effect of thiazide-type diuretics and may increase the risk of acute kidney injury in volume-depleted patients. Potassium effects of the two drugs oppose each other and are not clinically predictable.
What this interaction means in plain words
Chlorthalidone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, counteracting diuretic action.
What to do
Monitor blood pressure, renal function and electrolytes, and adjust the diuretic dose as required. Keep patients well hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Sulindac?
MediHelp rates the interaction as moderate. Chlorthalidone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive and diuretic effect of thiazide-type diuretics and may increase the risk of acute kidney injury in volume-depleted patients. Potassium effects of the two drugs oppose each other and are not clinically predictable.
How serious is the interaction between Chlorthalidone and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and adjust the diuretic dose as required. Keep patients well hydrated.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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