Drug interactions
Chlorthalidone + Treprostinil
Severity: Minor
Chlorthalidone and Treprostinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator, and combining it with a diuretic such as chlorthalidone may produce additive blood pressure lowering. Patients may notice dizziness or symptomatic hypotension, especially when starting or increasing doses.
What this interaction means in plain words
Chlorthalidone and Treprostinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorthalidone belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect: vasodilation from treprostinil plus volume depletion and vasodilation from the diuretic.
What to do
Monitor blood pressure and symptoms of hypotension when starting or titrating either drug, and reduce the diuretic dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorthalidone
Other interactions of Treprostinil
Frequently asked questions
Can I take Chlorthalidone with Treprostinil?
MediHelp rates the interaction as minor. Chlorthalidone and Treprostinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Treprostinil is a potent vasodilator, and combining it with a diuretic such as chlorthalidone may produce additive blood pressure lowering. Patients may notice dizziness or symptomatic hypotension, especially when starting or increasing doses.
How serious is the interaction between Chlorthalidone and Treprostinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or titrating either drug, and reduce the diuretic dose if hypotension occurs.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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