Drug interactions
Chlorthalidone + Umeclidinium-vilanterol
Severity: Moderate
Chlorthalidone and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone can lower serum potassium, and vilanterol, a long-acting beta2-agonist, can also shift potassium into cells. Together they may produce clinically relevant hypokalemia and ECG changes, particularly if the beta-agonist dose is exceeded or in patients with cardiac disease.
What this interaction means in plain words
Chlorthalidone and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorthalidone belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive hypokalemia from renal potassium loss caused by the thiazide-like diuretic and beta2-mediated intracellular potassium shift.
What to do
Monitor serum potassium periodically, especially at initiation and in patients with heart disease or hypoxia. Replace potassium as needed and make sure the inhaler is not used above the labeled dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorthalidone and Umeclidinium-vilanterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Umeclidinium-vilanterol
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Chlorthalidone with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Chlorthalidone and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone can lower serum potassium, and vilanterol, a long-acting beta2-agonist, can also shift potassium into cells. Together they may produce clinically relevant hypokalemia and ECG changes, particularly if the beta-agonist dose is exceeded or in patients with cardiac disease.
How serious is the interaction between Chlorthalidone and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, especially at initiation and in patients with heart disease or hypoxia. Replace potassium as needed and make sure the inhaler is not used above the labeled dose.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
