Drug interactions
Chlorzoxazone + Clonazepam
Severity: Moderate
Chlorzoxazone and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonazepam and chlorzoxazone both depress the CNS, so together they can cause marked sedation, ataxia, impaired cognition and falls. Respiratory depression is possible in vulnerable patients.
What this interaction means in plain words
Chlorzoxazone and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Clonazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABAergic and central depressant effects.
What to do
Use the lowest effective doses and monitor for oversedation, especially in older adults. Advise against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorzoxazone and Clonazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorzoxazone
Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Chlorzoxazone with Clonazepam?
MediHelp rates the interaction as moderate. Chlorzoxazone and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonazepam and chlorzoxazone both depress the CNS, so together they can cause marked sedation, ataxia, impaired cognition and falls. Respiratory depression is possible in vulnerable patients.
How serious is the interaction between Chlorzoxazone and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation, especially in older adults. Advise against alcohol and driving.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
