Drug interactions
Chlorzoxazone + Clozapine
Severity: Moderate
Chlorzoxazone and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is highly sedating and may also cause orthostatic hypotension, and chlorzoxazone can add to these effects. Combined use may increase somnolence, dizziness and falls.
What this interaction means in plain words
Chlorzoxazone and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Clozapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Monitor sedation and orthostatic blood pressure, and counsel the patient about driving. Reduce the dose of one agent if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Chlorzoxazone with Clozapine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is highly sedating and may also cause orthostatic hypotension, and chlorzoxazone can add to these effects. Combined use may increase somnolence, dizziness and falls.
How serious is the interaction between Chlorzoxazone and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, and counsel the patient about driving. Reduce the dose of one agent if oversedation occurs.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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