Drug interactions
Chlorzoxazone + Cyproheptadine
Severity: Moderate
Chlorzoxazone and Cyproheptadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine is a sedating antihistamine and chlorzoxazone is a centrally acting muscle relaxant that also causes drowsiness. Together they may produce excessive sedation, dizziness and impaired coordination.
What this interaction means in plain words
Chlorzoxazone and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Cyproheptadine belongs to Respiratory.
Why it happens
Additive CNS depressant effects.
What to do
Counsel patients to avoid driving and alcohol, and reduce the dose of one agent if daytime drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Cyproheptadine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyproheptadine is a sedating antihistamine and chlorzoxazone is a centrally acting muscle relaxant that also causes drowsiness. Together they may produce excessive sedation, dizziness and impaired coordination.
How serious is the interaction between Chlorzoxazone and Cyproheptadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and alcohol, and reduce the dose of one agent if daytime drowsiness occurs.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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