Drug interactions
Chlorzoxazone + Diphenoxylate-atropine
Severity: Moderate
Chlorzoxazone and Diphenoxylate-atropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorzoxazone is a centrally acting muscle relaxant that causes drowsiness. Combined with diphenoxylate, sedation and psychomotor impairment may be increased.
What this interaction means in plain words
Chlorzoxazone and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression.
What to do
Counsel on drowsiness, avoid alcohol and driving, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Diphenoxylate-atropine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorzoxazone is a centrally acting muscle relaxant that causes drowsiness. Combined with diphenoxylate, sedation and psychomotor impairment may be increased.
How serious is the interaction between Chlorzoxazone and Diphenoxylate-atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness, avoid alcohol and driving, and use the lowest effective doses.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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