Drug interactions
Chlorzoxazone + Doxylamine
Severity: Moderate
Chlorzoxazone and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating antihistamine commonly used as a sleep aid, and it can enhance chlorzoxazone-induced drowsiness. Next-day impairment and falls may occur.
What this interaction means in plain words
Chlorzoxazone and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Doxylamine belongs to Respiratory.
Why it happens
Additive CNS depression.
What to do
Counsel on drowsiness and avoid driving. Avoid or minimize use in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Doxylamine
Frequently asked questions
Can I take Chlorzoxazone with Doxylamine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating antihistamine commonly used as a sleep aid, and it can enhance chlorzoxazone-induced drowsiness. Next-day impairment and falls may occur.
How serious is the interaction between Chlorzoxazone and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoid driving. Avoid or minimize use in older adults.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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