Drug interactions
Chlorzoxazone + Lorazepam
Severity: Moderate
Chlorzoxazone and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines and centrally acting muscle relaxants both depress the CNS, so the combination can cause marked drowsiness, impaired coordination and, at higher doses, respiratory depression. Older or frail patients are at particular risk of falls.
What this interaction means in plain words
Chlorzoxazone and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABAergic benzodiazepine action plus sedative muscle relaxant effects.
What to do
Use the lowest effective doses for the shortest duration and monitor for sedation and respiratory depression. Warn patients against alcohol and driving, and take extra care in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Lorazepam
Frequently asked questions
Can I take Chlorzoxazone with Lorazepam?
MediHelp rates the interaction as moderate. Chlorzoxazone and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines and centrally acting muscle relaxants both depress the CNS, so the combination can cause marked drowsiness, impaired coordination and, at higher doses, respiratory depression. Older or frail patients are at particular risk of falls.
How serious is the interaction between Chlorzoxazone and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and monitor for sedation and respiratory depression. Warn patients against alcohol and driving, and take extra care in elderly patients.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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