Drug interactions
Chlorzoxazone + Methadone
Severity: Moderate
Chlorzoxazone and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorzoxazone is a centrally acting muscle relaxant that adds to the sedative effect of methadone. The combination can increase drowsiness, dizziness and the risk of respiratory depression.
What this interaction means in plain words
Chlorzoxazone and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Methadone belongs to Musculoskeletal.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and counsel the patient about sedation and avoiding driving. Monitor sedation and respiratory status, especially after dose increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Chlorzoxazone with Methadone?
MediHelp rates the interaction as moderate. Chlorzoxazone and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorzoxazone is a centrally acting muscle relaxant that adds to the sedative effect of methadone. The combination can increase drowsiness, dizziness and the risk of respiratory depression.
How serious is the interaction between Chlorzoxazone and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel the patient about sedation and avoiding driving. Monitor sedation and respiratory status, especially after dose increases.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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