Drug interactions
Chlorzoxazone + Nortriptyline
Severity: Moderate
Chlorzoxazone and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nortriptyline has sedative and anticholinergic effects that can add to chlorzoxazone-induced drowsiness. Dizziness, psychomotor slowing and falls may become more likely.
What this interaction means in plain words
Chlorzoxazone and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive CNS depression, with tricyclic antihistaminic and anticholinergic effects.
What to do
Monitor for sedation and orthostatic symptoms, especially in older adults. Reduce the dose of either drug if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Chlorzoxazone with Nortriptyline?
MediHelp rates the interaction as moderate. Chlorzoxazone and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nortriptyline has sedative and anticholinergic effects that can add to chlorzoxazone-induced drowsiness. Dizziness, psychomotor slowing and falls may become more likely.
How serious is the interaction between Chlorzoxazone and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic symptoms, especially in older adults. Reduce the dose of either drug if oversedation occurs.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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