Drug interactions
Chlorzoxazone + Oxazepam
Severity: Moderate
Chlorzoxazone and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so together they can cause increased drowsiness, poor coordination and slowed reactions. Respiratory depression is possible at higher doses, and older adults are at higher risk of falls.
What this interaction means in plain words
Chlorzoxazone and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and muscle relaxant sedation.
What to do
Use the lowest effective doses for the shortest time and monitor for sedation. Advise avoiding alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Chlorzoxazone with Oxazepam?
MediHelp rates the interaction as moderate. Chlorzoxazone and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so together they can cause increased drowsiness, poor coordination and slowed reactions. Respiratory depression is possible at higher doses, and older adults are at higher risk of falls.
How serious is the interaction between Chlorzoxazone and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and monitor for sedation. Advise avoiding alcohol and driving.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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