Drug interactions
Chlorzoxazone + Zuranolone
Severity: Moderate
Chlorzoxazone and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can deepen sedation and further impair psychomotor performance, including driving ability. Zuranolone labeling already warns of impaired driving and additive effects with other CNS depressants.
What this interaction means in plain words
Chlorzoxazone and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Zuranolone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression from zuranolone (a GABA-A positive modulator) and the centrally acting muscle relaxant chlorzoxazone.
What to do
If both are needed, consider lowering the dose of one or both and counsel the patient to avoid driving and hazardous tasks. Monitor for excessive sedation and reassess the need for the muscle relaxant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Chlorzoxazone with Zuranolone?
MediHelp rates the interaction as moderate. Chlorzoxazone and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can deepen sedation and further impair psychomotor performance, including driving ability. Zuranolone labeling already warns of impaired driving and additive effects with other CNS depressants.
How serious is the interaction between Chlorzoxazone and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If both are needed, consider lowering the dose of one or both and counsel the patient to avoid driving and hazardous tasks. Monitor for excessive sedation and reassess the need for the muscle relaxant.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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