Drug interactions
Cholera vaccine + Clarithromycin
Severity: Moderate
Cholera vaccine and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated cholera vaccine relies on viable bacteria colonizing the gut. Systemic antibiotics active against the vaccine strain may reduce its viability and the immune response, leaving patients inadequately protected.
What this interaction means in plain words
Cholera vaccine and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live vaccine strain reduces vaccine replication and immunogenicity.
What to do
Do not give the vaccine within 14 days after antibiotic use, and delay antibiotics until at least 10 days after vaccination if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Cholera vaccine with Clarithromycin?
MediHelp rates the interaction as moderate. Cholera vaccine and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral live attenuated cholera vaccine relies on viable bacteria colonizing the gut. Systemic antibiotics active against the vaccine strain may reduce its viability and the immune response, leaving patients inadequately protected.
How serious is the interaction between Cholera vaccine and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine within 14 days after antibiotic use, and delay antibiotics until at least 10 days after vaccination if feasible.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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