Drug interactions
Cholera vaccine + Gemcitabine
Severity: Moderate
Cholera vaccine and Gemcitabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemcitabine suppresses the bone marrow and immune function, which can reduce the antibody response to the cholera vaccine. Protection may be lower than expected.
What this interaction means in plain words
Cholera vaccine and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression impairs the immune response to vaccination.
What to do
Where possible, vaccinate at least 2 weeks before starting chemotherapy or defer until immune recovery. Consider revaccination after therapy if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemcitabine
Frequently asked questions
Can I take Cholera vaccine with Gemcitabine?
MediHelp rates the interaction as moderate. Cholera vaccine and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemcitabine suppresses the bone marrow and immune function, which can reduce the antibody response to the cholera vaccine. Protection may be lower than expected.
How serious is the interaction between Cholera vaccine and Gemcitabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate at least 2 weeks before starting chemotherapy or defer until immune recovery. Consider revaccination after therapy if given during treatment.
What other medicines interact with Gemcitabine?
MediHelp also lists interactions of Gemcitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Gemcitabine page.
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