Drug interactions
Cholera vaccine + Gentamicin
Severity: Moderate
Cholera vaccine and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The live oral cholera vaccine relies on viable bacteria colonizing the gut. Systemic gentamicin may reduce this and blunt immunity, though exposure in the gut is limited.
What this interaction means in plain words
Cholera vaccine and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain may reduce immunogenicity.
What to do
Delay cholera vaccination until the antibiotic course has finished, following the labeled interval of about 14 days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Cholera vaccine with Gentamicin?
MediHelp rates the interaction as moderate. Cholera vaccine and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The live oral cholera vaccine relies on viable bacteria colonizing the gut. Systemic gentamicin may reduce this and blunt immunity, though exposure in the gut is limited.
How serious is the interaction between Cholera vaccine and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay cholera vaccination until the antibiotic course has finished, following the labeled interval of about 14 days.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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