Drug interactions
Cholera vaccine + Hydroxycarbamide
Severity: Moderate
Cholera vaccine and Hydroxycarbamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral cholera vaccine is a live attenuated product. In a patient on hydroxyurea, the immune response may be reduced and vaccine strain infection is a theoretical concern.
What this interaction means in plain words
Cholera vaccine and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunosuppression from hydroxyurea may reduce the vaccine response and permit replication of the live strain.
What to do
Consider timing vaccination before starting hydroxyurea or after immune recovery. Assess risk against the need for travel protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Cholera vaccine with Hydroxycarbamide?
MediHelp rates the interaction as moderate. Cholera vaccine and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral cholera vaccine is a live attenuated product. In a patient on hydroxyurea, the immune response may be reduced and vaccine strain infection is a theoretical concern.
How serious is the interaction between Cholera vaccine and Hydroxycarbamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider timing vaccination before starting hydroxyurea or after immune recovery. Assess risk against the need for travel protection.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine, Stavudine, Adenovirus types 4 and 7 live. The full list is on the Hydroxycarbamide page.
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