Drug interactions
Cholera vaccine + Moxifloxacin
Severity: Major
Cholera vaccine and Moxifloxacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated cholera vaccine relies on viable bacteria colonizing the gut. Systemic antibiotics with activity against Vibrio cholerae, such as moxifloxacin, may kill the vaccine strain and reduce the immune response.
What this interaction means in plain words
Cholera vaccine and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Antibacterial activity against the live attenuated vaccine strain reduces vaccine efficacy.
What to do
Do not give the oral cholera vaccine to patients who have taken systemic antibiotics within 14 days, per labeling. Delay vaccination until antibiotic therapy is complete.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Cholera vaccine with Moxifloxacin?
MediHelp rates the interaction as major. Cholera vaccine and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The oral live attenuated cholera vaccine relies on viable bacteria colonizing the gut. Systemic antibiotics with activity against Vibrio cholerae, such as moxifloxacin, may kill the vaccine strain and reduce the immune response.
How serious is the interaction between Cholera vaccine and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the oral cholera vaccine to patients who have taken systemic antibiotics within 14 days, per labeling. Delay vaccination until antibiotic therapy is complete.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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