Drug interactions
Cholera vaccine + Sirolimus
Severity: Moderate
Cholera vaccine and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may reduce the immune response to oral cholera vaccine, leaving the patient incompletely protected. The vaccine is live-attenuated in some forms, which adds a theoretical infection concern in immunosuppressed patients.
What this interaction means in plain words
Cholera vaccine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sirolimus inhibits mTOR-mediated lymphocyte proliferation, which blunts vaccine response.
What to do
Vaccinate before starting immunosuppression if possible. Check the product type and avoid live-attenuated vaccine in immunosuppressed patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Cholera vaccine with Sirolimus?
MediHelp rates the interaction as moderate. Cholera vaccine and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus may reduce the immune response to oral cholera vaccine, leaving the patient incompletely protected. The vaccine is live-attenuated in some forms, which adds a theoretical infection concern in immunosuppressed patients.
How serious is the interaction between Cholera vaccine and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting immunosuppression if possible. Check the product type and avoid live-attenuated vaccine in immunosuppressed patients.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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