Drug interactions
Cholera vaccine + Tacrolimus
Severity: Moderate
Cholera vaccine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression with tacrolimus may blunt the antibody response to cholera vaccine, leaving the patient less protected. The vaccine is inactivated or non-replicating so safety concerns are limited.
What this interaction means in plain words
Cholera vaccine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through calcineurin inhibition suppressing T-cell-dependent immune responses.
What to do
Where possible vaccinate before starting immunosuppression or ahead of travel with adequate lead time. Do not rely on the vaccine alone and reinforce food and water precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Cholera vaccine with Tacrolimus?
MediHelp rates the interaction as moderate. Cholera vaccine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression with tacrolimus may blunt the antibody response to cholera vaccine, leaving the patient less protected. The vaccine is inactivated or non-replicating so safety concerns are limited.
How serious is the interaction between Cholera vaccine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible vaccinate before starting immunosuppression or ahead of travel with adequate lead time. Do not rely on the vaccine alone and reinforce food and water precautions.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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