Drug interactions
Cholestyramine + Deflazacort
Severity: Moderate
Cholestyramine and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine may bind oral deflazacort in the gut and reduce its absorption. Reduced corticosteroid exposure may lessen therapeutic effect.
What this interaction means in plain words
Cholestyramine and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Deflazacort belongs to Miscellaneous.
Why it happens
Resin binding in the gastrointestinal tract reduces absorption of deflazacort.
What to do
Give deflazacort at least 4 hours before cholestyramine. Monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholestyramine
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Cholestyramine with Deflazacort?
MediHelp rates the interaction as moderate. Cholestyramine and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine may bind oral deflazacort in the gut and reduce its absorption. Reduced corticosteroid exposure may lessen therapeutic effect.
How serious is the interaction between Cholestyramine and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give deflazacort at least 4 hours before cholestyramine. Monitor clinical response.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
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