Drug interactions
Cholestyramine + Meloxicam
Severity: Moderate
Cholestyramine and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine binds oral meloxicam in the gut and reduces its absorption and half-life, which may lessen analgesic effect. The interaction is used deliberately to hasten meloxicam elimination in overdose.
What this interaction means in plain words
Cholestyramine and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
Anion exchange resin binds meloxicam in the intestine and interrupts its enterohepatic recirculation.
What to do
Give meloxicam at least 1 hour before or 4 to 6 hours after cholestyramine, and monitor analgesic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Meloxicam?
MediHelp rates the interaction as moderate. Cholestyramine and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine binds oral meloxicam in the gut and reduces its absorption and half-life, which may lessen analgesic effect. The interaction is used deliberately to hasten meloxicam elimination in overdose.
How serious is the interaction between Cholestyramine and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give meloxicam at least 1 hour before or 4 to 6 hours after cholestyramine, and monitor analgesic response.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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