Drug interactions
Cholestyramine + Minocycline
Severity: Moderate
Cholestyramine and Minocycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine may bind minocycline in the gut and reduce absorption, potentially lowering antibiotic effect.
What this interaction means in plain words
Cholestyramine and Minocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Minocycline belongs to Anti Bacterial.
Why it happens
Anion-exchange resin binds tetracycline in the gastrointestinal lumen, reducing absorption.
What to do
Separate dosing, giving minocycline at least 1 to 2 hours before or 4 to 6 hours after cholestyramine. Monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Minocycline
- Acitretin + Minocycline Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Cholera vaccine + Minocycline Major
- Methoxyflurane + Minocycline Major
- Minocycline + Palovarotene Major
- Minocycline + Pexidartinib Major
Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Minocycline?
MediHelp rates the interaction as moderate. Cholestyramine and Minocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine may bind minocycline in the gut and reduce absorption, potentially lowering antibiotic effect.
How serious is the interaction between Cholestyramine and Minocycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate dosing, giving minocycline at least 1 to 2 hours before or 4 to 6 hours after cholestyramine. Monitor clinical response.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Cholera vaccine. The full list is on the Minocycline page.
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