Drug interactions
Cholic acid + Losartan
Severity: Moderate
Cholic acid and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan may inhibit the bile salt export pump, which could promote accumulation of bile salts in hepatocytes when taken with cholic acid. This could raise the risk of liver injury.
What this interaction means in plain words
Cholic acid and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Losartan belongs to Cardiovascular.
Why it happens
Possible inhibition of BSEP-mediated bile salt efflux by losartan.
What to do
If used together, monitor serum transaminases and bilirubin. Stop cholic acid or review the combination if liver tests worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Losartan?
MediHelp rates the interaction as moderate. Cholic acid and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Losartan may inhibit the bile salt export pump, which could promote accumulation of bile salts in hepatocytes when taken with cholic acid. This could raise the risk of liver injury.
How serious is the interaction between Cholic acid and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If used together, monitor serum transaminases and bilirubin. Stop cholic acid or review the combination if liver tests worsen.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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