Drug interactions
Cholic acid + Rosiglitazone
Severity: Moderate
Cholic acid and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosiglitazone may inhibit the bile salt export pump, which could contribute to accumulation of bile salts in hepatocytes alongside cholic acid therapy. This could raise liver injury risk in susceptible patients.
What this interaction means in plain words
Cholic acid and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Rosiglitazone belongs to Endocrine.
Why it happens
Inhibition of BSEP by rosiglitazone reduces biliary efflux of bile acids.
What to do
Monitor serum transaminases and bilirubin if the combination is needed. Stop or reassess therapy if liver injury signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cholic acid and Rosiglitazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Cholic acid
Frequently asked questions
Can I take Cholic acid with Rosiglitazone?
MediHelp rates the interaction as moderate. Cholic acid and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rosiglitazone may inhibit the bile salt export pump, which could contribute to accumulation of bile salts in hepatocytes alongside cholic acid therapy. This could raise liver injury risk in susceptible patients.
How serious is the interaction between Cholic acid and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum transaminases and bilirubin if the combination is needed. Stop or reassess therapy if liver injury signs appear.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
