Drug interactions
Insulin degludec-liraglutide + Rosiglitazone
Severity: Major
Insulin degludec-liraglutide and Rosiglitazone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosiglitazone improves insulin sensitivity, and combining it with insulin and liraglutide adds to the glucose-lowering effect and the risk of hypoglycemia. Rosiglitazone with insulin also increases the risk of edema and heart failure.
What this interaction means in plain words
Insulin degludec-liraglutide and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec-liraglutide belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Why it happens
Additive glucose lowering from insulin sensitization combined with insulin and GLP-1 receptor agonism, with thiazolidinedione-related fluid retention.
What to do
Avoid the combination where possible, particularly in patients with or at risk of heart failure. If used, monitor glucose, reduce the insulin dose as needed and watch for edema and weight gain.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec + Rosiglitazone Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Rosiglitazone?
MediHelp rates the interaction as major. Insulin degludec-liraglutide and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rosiglitazone improves insulin sensitivity, and combining it with insulin and liraglutide adds to the glucose-lowering effect and the risk of hypoglycemia. Rosiglitazone with insulin also increases the risk of edema and heart failure.
How serious is the interaction between Insulin degludec-liraglutide and Rosiglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly in patients with or at risk of heart failure. If used, monitor glucose, reduce the insulin dose as needed and watch for edema and weight gain.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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