Drug interactions
Insulin aspart + Rosiglitazone
Severity: Major
Insulin aspart and Rosiglitazone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosiglitazone with insulin increases the risk of edema, heart failure and possibly ischemic cardiac events, and the glucose-lowering effects are additive. Hypoglycemia may occur.
What this interaction means in plain words
Insulin aspart and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin aspart belongs to Endocrine; Rosiglitazone belongs to Endocrine.
Why it happens
PPAR-gamma-mediated renal sodium and fluid retention compounded by insulin, plus additive glucose lowering.
What to do
Monitor for edema, rapid weight gain and heart failure symptoms; avoid in patients with heart failure. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin aspart
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
- Insulin degludec + Rosiglitazone Major
Frequently asked questions
Can I take Insulin aspart with Rosiglitazone?
MediHelp rates the interaction as major. Insulin aspart and Rosiglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rosiglitazone with insulin increases the risk of edema, heart failure and possibly ischemic cardiac events, and the glucose-lowering effects are additive. Hypoglycemia may occur.
How serious is the interaction between Insulin aspart and Rosiglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for edema, rapid weight gain and heart failure symptoms; avoid in patients with heart failure. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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