Drug interactions
Choline magnesium trisalicylate + Clomipramine
Severity: Moderate
Choline magnesium trisalicylate and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine blocks serotonin reuptake into platelets, which impairs platelet aggregation, and salicylates add their own antiplatelet effect and gastric mucosal injury. Together they raise the risk of gastrointestinal and other bleeding.
What this interaction means in plain words
Choline magnesium trisalicylate and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet function (serotonin depletion plus cyclooxygenase inhibition) together with salicylate-related mucosal irritation.
What to do
Monitor for signs of GI bleeding such as melena, hematemesis and falling hemoglobin, especially in older patients or those with ulcer history. Consider gastroprotection or a non-salicylate analgesic if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Clomipramine?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine blocks serotonin reuptake into platelets, which impairs platelet aggregation, and salicylates add their own antiplatelet effect and gastric mucosal injury. Together they raise the risk of gastrointestinal and other bleeding.
How serious is the interaction between Choline magnesium trisalicylate and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding such as melena, hematemesis and falling hemoglobin, especially in older patients or those with ulcer history. Consider gastroprotection or a non-salicylate analgesic if bleeding risk is high.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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