Drug interactions
Choline magnesium trisalicylate + Edoxaban
Severity: Moderate
Choline magnesium trisalicylate and Edoxaban: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at analgesic doses inhibit platelets and can irritate the gastric mucosa, adding to the bleeding risk of edoxaban. Non-acetylated salicylates have weaker platelet effects than aspirin, but GI risk remains.
What this interaction means in plain words
Choline magnesium trisalicylate and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect on hemostasis with salicylate-related mucosal injury.
What to do
Monitor for bleeding signs and hemoglobin, and prefer acetaminophen for analgesia where possible. Limit the salicylate dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Edoxaban?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Edoxaban can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at analgesic doses inhibit platelets and can irritate the gastric mucosa, adding to the bleeding risk of edoxaban. Non-acetylated salicylates have weaker platelet effects than aspirin, but GI risk remains.
How serious is the interaction between Choline magnesium trisalicylate and Edoxaban?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and hemoglobin, and prefer acetaminophen for analgesia where possible. Limit the salicylate dose and duration.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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