Drug interactions
Choline magnesium trisalicylate + Fluvoxamine
Severity: Moderate
Choline magnesium trisalicylate and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates inhibit platelet function and can irritate the gastric mucosa, and fluvoxamine further impairs platelet aggregation. The combination raises the risk of bleeding, notably in the upper gastrointestinal tract.
What this interaction means in plain words
Choline magnesium trisalicylate and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet dysfunction from reduced platelet serotonin and salicylate-mediated COX inhibition, plus mucosal injury.
What to do
Monitor for GI bleeding and anemia, and consider gastroprotection in at-risk patients. Use the lowest effective salicylate dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Choline magnesium trisalicylate with Fluvoxamine?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates inhibit platelet function and can irritate the gastric mucosa, and fluvoxamine further impairs platelet aggregation. The combination raises the risk of bleeding, notably in the upper gastrointestinal tract.
How serious is the interaction between Choline magnesium trisalicylate and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and anemia, and consider gastroprotection in at-risk patients. Use the lowest effective salicylate dose for the shortest time.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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