Drug interactions
Choline magnesium trisalicylate + Losartan
Severity: Moderate
Choline magnesium trisalicylate and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At anti-inflammatory doses, salicylates can blunt the antihypertensive effect of losartan and increase the risk of renal impairment, especially in elderly or volume-depleted patients.
What this interaction means in plain words
Choline magnesium trisalicylate and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate inhibition of renal prostaglandin synthesis reduces renal perfusion and opposes ARB effects.
What to do
Maintain hydration and monitor blood pressure, creatinine and potassium. Consider paracetamol if analgesia is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Choline magnesium trisalicylate with Losartan?
MediHelp rates the interaction as moderate. Choline magnesium trisalicylate and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At anti-inflammatory doses, salicylates can blunt the antihypertensive effect of losartan and increase the risk of renal impairment, especially in elderly or volume-depleted patients.
How serious is the interaction between Choline magnesium trisalicylate and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor blood pressure, creatinine and potassium. Consider paracetamol if analgesia is needed.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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